Sildenafil (trade name Viagra et al.) Is a drug developed by Pfizer. This drug company is a US multinational one and it is the largest in the world. Of course, it is not only Sildenafil that comes from Pfitzer, but also medicines like Lipitor, Diflucan and Metformin come from this pharmaceutical company.
From the outset, it was thought that Sildenafil would be used to treat angina pectoris. What happened, however, was that these attempts did not work well at all, but instead, it was noted that prolonged erection, or welcome erection by impotence in men was a common adverse reaction.
This led to Pfitzer’s decision to test the drug for its effect on impotence instead, resulting in the medicine we today know as Viagra and many others.
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Sildenafil in various forms
Sildenafil is available in various forms. You can get sildenafil printed on recipes in one of the following ways:
- Tablets in the strengths 20, 25, 50 or 100 mg
- Liquid form (suspension swallowed)
- Injection liquid (available in hospital)
Sildenafil is also used for high blood pressure in the blood vessels of the lungs (PHA – pulmonary arterial hypertension).
Sildenafil – more names than Viagra
Sildenafil is the active substance / active substance in Viagra, which means that it is just like with different variants of, for example, paracetamol. With paracetamol as an active substance, we can find medicines such as Panodil, Alvedon, Pamol, and more. They have all paracetamol as the active substance, which means that all these different drugs function in the same way.
When it comes to sildenafil, it’s the best known drug name Viagra, but it’s far from the only name this drug goes under. The drug itself belongs to a drug group called PDE5 inhibitor.
Different manufacturers have different names on the product and here are a few examples:
- rip City
- Sildenafil 1A Farma
- Sildenafil Accord
- Sildenafil Actavis
- Sildenafil Navamedic
- Sildenafil Pfitzer
- Sildenafil STADA
- Sildenafil Teva
- Sildenafil Teva Pharma
It works in such a way that when the patent period expires on a drug, it is allowed for other manufacturers to start making copies of the original. These copies are called generic drugs and therefore contain the same active substance, but are sold under a different name.
The price may in some cases differ depending on which of the different medicines you buy, and this is one of the things that happens when the patent expires. With lower prices for medicines with the same active substance, other manufacturers can compete with the previous patent holder and that’s also what’s happening.
There are no better or worse variants, but all variants are as good. You do not have to worry about getting a prescription printed on a non-original medicine. It works the same way, so it’s only names and packages that differ.
It may also be that the excipients in the medicine differ. In some cases, therefore, two substitutable drugs with different excipients affect a person in different ways. It may be that you do not tolerate an aid, for example.
How does sildenafil work?
Sildenafil works in such a way that it inhibits a particular enzyme in the body called phosphodiesterase type 5 and it causes 1) blood flow to the penis to increase blood cells (it does not produce any effect without sexual stimulation) or 2 ) that it reduces blood pressure in the lungs by widening the blood vessels in the lungs.
So, what is so more precise as happens in the body when using sildenafil when the goal is to treat erectile dysfunction? Well, what happens is that the subject addresses erection problems by affecting physiological processes that occur in connection with sexual stimulation. This does not mean that the substance increases sex drive, but it facilitates the body to achieve erection.
What happens is a release of nitric oxide in the penile swelling bodies, which causes the enzyme guanylate cyclase to be activated. When this happens, cGMP (cyclic Guanosin monophosphate) increases and, in turn, allows the smooth muscle to relax and this results in erection when the swelling bodies are filled with blood.
The erection is maintained by closing the effluent by the pressure of the inflating blood, or with certain muscle groups, and this means that the penis can continue to be filled with blood. The effluent continues to be shut down until the sexual stimulation ceases or after the man has been triggered.
For men with severe difficulty in achieving erection, this means that it becomes much easier to get erections and for men with less erection problems, the use of sildenafil in one form or another results in the erection becoming both more reliable and more hard than normal.
Possible side effects
As with other medicines, there is always a risk of one or more side effects after taking a new medicine. There are more common and less common side effects and it is individual how to respond to sildenafil.
Often, adverse side effects disappear with time, so you can continue the medication in many cases until the side effects disappear by themselves. This applies to the side effects that can be found on the package leaflet or as the doctor who has written the recipe has told you. Instead, if you experience side effects not mentioned, contact your healthcare provider immediately, as it may mean that you are extra sensitive to something or worse.
As for the type of side effects not listed among those listed on the package leaflet, but as you know, it may not be easy to realize that it is just a side effect of the medicine, but usually you can put together one and one and realize that’s how it matters. If something happens in the body that you are not used to after starting a new medicine, the risk is great that it is an adverse drug reaction, although it may be a very unusual one. You should therefore take this seriously, as such side effects may be even more dangerous than those mentioned by your doctor or included in the information on the package leaflet.
When it comes to side effects of a drug, they are divided into “common”, “less common” and “rare”, which is a good way, as it makes it easier for you as a patient to get a quick overview of what to expect and what is less common. For sildenafil, according to FASS.se, the following side effects apply:
Very common side effects (may affect more than 1 user in 10): headache,
Common side effects (may affect up to 1 in 10 users): nausea, facial redness, hot flushes, digestive problems, altered color vision, vision vision, vision disturbances, nasal congestion and dizziness
LEAVING common side effects (may affect up to 1 in 100 people): vomiting, skin rashes, eye irritation, blood blurred eyes / redness, eye pain, seeing light flashes or perceiving light as very strong, photosensitivity, watery eyes, palpitation, rapid heartbeat, high blood pressure low blood pressure, muscle aches, sleepiness, decreased feeling, scams, ears, dry mouth, blocked or congested sinuses, inflammation of the mucous membrane of the nose, upper stomach ache, gastroesophageal reflux disease, presence of blood in the urine, nose bleeding, warmth and tiredness
Severe side effects (may affect up to 1 in 1,000 users): fainting, stroke, heart attack, irregular heartbeat, temporarily reduced blood flow to parts of the brain, feeling tight in throat, numb mouth, bleeding in the back of the eye , double vision, decreased visual acuity, abnormal sensation of the eye, eye swelling or eyelid, small dots or spots in the field of vision, seeing a gloria around light sources, expanded pupils. bleeding in the penis, blood in the spinal fluid, dry nose, swelling inside the nose, lameness and sudden loss or loss of hearing
To consider when using Sildenafil
You should not use sildenafil while using nitrates (used to relieve vaginal cramps), as you may risk having a high blood pressure drop. This, in turn, may trigger a vascular accident or a heart attack.
Nor should you combine sildenafil with amyl nitrite, as it can give the same effect as nitrates (see above). This is initially a cardiovascular medicine, but it is used in Sweden for longer.
Grapefruit is another thing you should not eat while using sildenafil. This is not only valid for sildenafil, but it is generally advisable to be careful about grapefruit when eating medicine. Grapefruit in all forms, including juices, can reduce the body’s ability to get rid of the drug, and then you can get stronger effects of the drug, which increases the risk of side effects.
If you take other medicines at the same time there is always the risk that they affect each other. Among other things, it may be that the dose of a drug needs to be changed as the doctor can help you.
If you are eating herbal remedies of one kind or another, it is important to consult with a doctor even then. It may be that the herbal remedy you eat may crash with your other medicine and it is dangerous.
You should also not take Sildenafil while using other treatments for impotence without consulting your doctor first.